Title: Comparison of latanoprost and timolol in patients with primary open-angle glaucoma and ocular hypertension
Abstract: Objective To compare the ocular hypotensive efficacy and side effects of latanoprost(PhXA41),a new phenyl-substituted prostaglandin F 2α -isopropyl ester analogue,with timolol in patients with elevated intraoular pressure(IOP).Methods A total of 34 patients(66 eyes) with primary open-angle glaucoma or ocular hypertension were randomized,17(32 eyes)to latanoprost,another 17(34 eyes)to timolol.The patients received either 0.05g·L -1 latanoprost once daily or 5g·L -1 timolol twice daily for a period of 12 weeds.Results IOP was significantly lowered ( P0.001) and maintained by both medications over 12 weeks.At all visits,the efficacy of latanoprost was statistically superior to timolol( P0.05%) . Latanoprost reduced IOP at the end of 12 weeks by 9.5±3.1mmHg(36.8%)(1mmHg=0.133kPa),while timolol reduced IOP by 7.4±2.6mmHg (29.6%)( P0.01) . Latanoprost induced a slight increase in conjunctival hyperemia in 23.5% of treated patients,compared with 11.8% for timolol.Sporadic episodes of mild punctate corneal epithelial erosions were observed in latanoprost-treated eyes. The heart rate dropped by 4 beats per minute in timolol group ( P0.05 ).Conclusion It was demonstrated that 0.05g·L -1 latanoprost taken once daily is well tolerated and more effective in reducing IOP than 5g·L -1 timolol taken twice daily.Thus,latanoprost has the potential of becoming an excellent candidate for glaucoma medication.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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