Title: A Comparative Study of Latanoprost and Timolol in Treating Patients With Glaucoma or Ocular Hypertension
Abstract: OBJECTIVE:To confirm the efficacy and safety of latanoprost in treating glaucoma METHODS:In a double blind,randomized control clinical trial,we compared the efficacy and adverse drug reactions of once daily topically applied 0 005% latanoprost with those of twice daily 0 5% timolol for 12 weeks in patients with open angle glaucoma or ocular hypertension RESULTS:The study included 46 patients(22 pts randomized to latanoprost treatment,24 pts to timolol),46 patients remained at the end of the study Comparing with baseline diurnal intraocular pressure(IOP),the IOP reduction(mean±standard deviation)achieved with latanoprost(7 86±2 39)mmHg,(31 1%,P0 001),and timolol (6 24±2 58)mmHg(24 9%,P0 001),the difference between the two groups(1 62mmHg)being significant(P0 01) Two patients treated with latanoprost had foreign body sensation No other ocular and systemic adverse reactions related to the two drugs were found CONCLUSION:The results of this study demonstrated that 0 005% latanoprost applied once daily is well tolerated and more effective in reducing IOP than 0 5% timolol applied twice daily Thus,latanoprost has the potential for becoming one of the ideal antiglaucoma drugs
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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