Title: Comparison of the effects of different analgesics in preventing postoperative hyperalgesia after remifentanil-based TIVA
Abstract: Objective To compare the effects of sulfentanil,tramadol and flurbiprofen in preventing postoperative hyperalgesia after remifentanil-based total intravenous anesthesia(TIVA).Methods Eighty patients undergoing middle ear operations with remifentanil and propofol based TIVA were randomly assigned to 4 groups: group S(sufentanil),group T(tramadol),group F(flurbiprofen) and group C(control).The patients were received sulfentanil 0.1 μg/kg,tramadol 2 mg/kg or flurbiprofen 1.5 mg/kg i.v.at 30 min before the end of operation,respectively.The dosages of narcotics during anesthesia,the extubation time and awareness time were recorded.The pain intensity was evaluated by vision assessment score(VAS) at the point of 10,30 min,4,24 hr after surgery.Results Compared with group T and C,the extubation time in S group was longer(P0.05).VAS scores in groups S and T were less than in groups C at 10,30 min after extubation(P0.05).When compared with the VAS within 4,24 h of postoperation,the scores of VAS at the postoperative point of 10 min and 30 min were significantly higher in the group F and C(P0.05).Conclusion Large dosages of remifentanil used during anesthesia may cause hyperalgesia after operation.Sulfentanil and tramadol not flurbiprofen can prevent hyperalgesia efficiently;but sulfentanil has longer recovery time.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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