Title: Preventive effect of tramadol on postoperative hyperalgesia after remifentanil-based anesthesia
Abstract: Objective To compare the efficacy and safety of tramadol and morphine for preventing and treating postoperative hyperalgesia after remifentanil-based anesthesia.Methods Sixty patients underwent lower abdominal operation were randomly divided into two groups(n=30 each):morphine group(M group) and tramadol group(T group).The venous anesthesia was taken using remifentanil(0.2 μg·kg-1·min-1) combining with propofol(6 mg·kg-1) in the two groups,and the doses mentioned above drugs were modified based on bispectral index(BIS) and hemodynamic indexes.At 20 min before finishing operation,morphine(0.15 mg·kg-1) was given in M group,and tramadol(3 mg·kg-1) was given in T group.At 5 min before finishing operation,pump infusion of propofol was stopped,but pump infusion of remifentanil was continued till ending the suture of skin.The time from stopping infusion of remifentanil to awaking,the hemodynamic indexes during pulling out tracheal cannula,the Visual Anaglogue Scale(VAS) at 30 min post awaking and postoperative nausea,vomiting and chill were observed.Results The awaking time was markedly postponed in M group compared with T group((13.10±2.34) vs(7.17± 1.56) min,P0.01).The hemodynamic indexes had no significant difference during pulling out cannula in two groups.The VAS were in effective analgesic range despite they had difference in two groups.The incidence of postoperative nausea and vomiting were all high,and the incidence of chilling in M group and T group had no significance(10.0% vs 0,P0.05).Conclusions Both tramadol and morphine have a better efficacy in preventing acute postoperative hyperalgesia of remifentanil-related venous anesthesia,but tramadol has less influence on delay of awakening and may reduce the occurrence of postoperative chills.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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