Title: Synthesis of 3,4- Dihydropyrimidine-2(1H)-one Derivatives Using H_3PW_(12)O_(40)/ TiO_2-SiO_2 as Catalyst
Abstract: The 3,4- Dihydropy- rimidine- 2(1H)- one derivatives was synthesized from substituted benzaldehyde,ethylacetoacetate and urea using H3PW12O40/ TiO2- SiO2 as a novel eco- friendly catalyst that was prepared by a sol- gel technique. The influences of molar ratio of reactant,reaction temperature,catalyst dosage and reaction time were discussed. Experimental results showed that H3PW12O40/ TiO2- SiO2 is a good catalyst to synthesize 3,4- dihydropy- rimidine- 2(1H)- one derivatives. When the dosage of substituted benzaldehyde is 0. 04 mol,n(substituted benzaldehyde) ∶ n( ethylacetoacetate) ∶ n( urea) = 1.0∶1.2∶1.5,the quantity of catalyst is 2. 5% of the feed stock,reaction temperature is 90 ℃ and reaction time is 75 min. The yield of 3,4-dihydropy- rimidine- 2( 1H)- one derivatives could reach 53. 7% ~ 94. 3%. The catalyst and synthesis products were characterized by IR,XRD,SEM,respectively.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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