Title: Expression of p53,PCNA,Ki-67 in thyroid carcinoma and its significance
Abstract: Objective:To investigate the relationship among the expression of p53,PCNA and Ki-67 proteins and clinicopathology of human thyroid carcinoma.Methods:Using SP immunohistochemical methods,the expression of p53,PCNA and Ki-67 proteins was detected in 92 cases of thyroid carcinoma.Results:The positive rate of p53 protein expression was 54.3%(50/92),PCNA was 56.9 %(52/92),and Ki-67 proliferative index was(12.01±3.32) % in thyroid carcinoma.A significant correlation was found among p53,PCNA expression and Ki-67 over expression and the depth of invasion and lymph node metastasis.Conclusion:A significant correlation was found among p53,PCNA expression and Ki-67 over expression and the depth of invasion and lymph node metastasis of cancer.The abnormal expression of p53,PCNA,Ki-67 has an important clinical value for early diagnosis,prognosis evaluation and proper treatment of thyroid carcinoma.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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