Title: Study on the Acute Toxicity and Anti-inflammatory Effect of the Ethanol Extract of Illigera rhodantha Hance
Abstract: Objective To study the acute toxicity and anti-inflammatory effect of the ethanol extract of Illigera rhodantha Hance.Methods Mice in experimental medicine group were intragastrically administered the ethanol extract of Illigera rhodantha Hance.by the thickest concentration and the largest volume permitted and were administered the equal solvent in control group,the acute toxicity reaction of mice was observed in the successive 14 days.The anti-inflammatory effect of the drug was studied with the swelling of ear induced by xylene in mice and the edema of paw induced by carrageenin in rats.Results After 14 days,all mice in the experimental medicine and control groups survived and the increasing rates of weight in the two groups were respectively 38.40% and 36.29%(P0.05),no acute toxicity was observed in both groups.The maximal tolerant dose(MTD) of the ethanol extract of Illigera rhodantha Hance.by ig in mice was 3063mg/kg.The swelling of ear induced by xylene in mice,the edema of paw induced by carrageenin in rats could be inhibited significantly by the ethanol extract of Illigera rhodantha Hance.Conclusion The ethanol extract of Illigera rhodantha Hance.has little acute toxicity in mice and significant anti-inflammatory effect.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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