Title: Diagnostic and prognostic value of microvessel density, vascular endothelial growth factor and endostatin in stage I clear cell renal cancer
Abstract: Objective To investigate the value of vascular endothelial growth factor(VEGF), endostatin and microvessel density(MVD) involving in the process of angiogenesis and in the diagnosis and prognosis of clear cell renal cell carcinoma. Methods 16 cases of stage Ⅰ clear cell RCC and 8 healthy controls were enrolled. The blood vessels were highlighted in sections by von Willebrand factor (vWF) immunohistochemistry. The MVD per high power field (×400) was measured in each case. Serum levels of VEGF and endostatin were detected by enzyme linked immunosorbent assay and compared with those of the healthy controls. The relationship between VEGF, endostatin and MVD concerning the tumor grade was determined. Results VEGF levels were highly correlated with endostatin levels among the renal cell carcinoma(RCC) patients but not in the controls. Additionally, VEGF was found to be significantly related to MVD and primary tumor volume. Neither the levels of VEGF and endostatin nor the MVD were correlated with the tumor grade of RCC. Conclusion Serum VEGF and endostatin level elevate in the early stage clear cell RCC and correlate with the tumor size. It has some potential value as an adjuvant for diagnosis and in assessment of prognosis. While MVD has no value in prognostic evaluation for early stage RCC.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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