Title: Pharmacokinetics of Amiodarone Dispersible Tablets in Human Plasma
Abstract: A LC-MS method was established for the determination of amiodarone in human plasma.According to a randomized crossover design,the pharmacokinetics after oral administration of amiodarone dispersible tablets (test preparation)and amiodarone tablets(reference preparation)in 18 healthy volunteers was investigated.The pharmacokinetic parameters of test and reference preparations were as follows:c_(max)(419.96±211.72)and(414.85±166.66)ng/ml,t_(max)(4.2±1.2)and(3.8±0.9)h,t_(1/2)(38.8±20.4)and(39.6±12.5)h,A UC_(0-96h)(6375.29±3093.14)and(6518.38±3101.07)ng·h·ml~(-1),AUC_(0→∞)(7165.29±3680.16)and(7325.51±3478.09)ng·h·ml~(-1),respectively.Relative bioavailability of test preparation was(98.37±8.38)%.The result of two one-side t test showed that the two preparations were bioequivalent.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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