Title: Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets
Abstract: Objective:To establish an HPLC-UV method for the assessment of pharmacokinetics and bioequiva- lence of terazosin.Methods:18 healthy Chinese male volunteers were randomized to administrate a single crossover dose of test or reference tablets(2 mg).The blood concentrations of terazosin from the volunteers at the certain time- points after the administration were measured by HPLC.The pharmaeokinetic parameters as well as relative bioavail- ability were analyzed based on variation analyses and two one-side t-test.Results:The main pharmacokinetic pa- rameters of terazosin were as follows:T_(max)(1.08±0.19)h and(1.08±0.19)h,C_(max)(320.49±44.82)ng·mL~(-1) and(316.03±45.40 )ng·mL~(-1),t_(1/2)(12.68±0.92)h and(12.97±1.33)h,AUC_(0→48)(2648.00±316.85)ng· h·mL~(-1)and(2618.67±334.38)ng·h·mL~(-1),AUC_(0→∞)(3002.46±322.25)ng·h·mL~(-1)and(2979.85± 341.96)ng·h·mL~(-1).Conclusion:The method is simple and reliable.The test formulation is bioequivalent to the reference formulation.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot