Title: Expression and clinical significance of IL-12 in acute cardiac allograft rejection in rats
Abstract: Objective To explore the expression and clinical significance of IL-12 in acute cardiac allograft rejection in rats.Methods Two groups of SD rats received cervical heterotopic heart transplantation from allogeneic Wistar or syngeneic SD rats.The cardiac grafts were harvested at 1,3,5,and 7 days after transplantation and detected for the expression of IL-12 mRNA by reverse transcriptional polymerase chain reaction(RT-PCR).Results With the posttransplantation day delayed,the expression of IL-12 mRNA was significantly increased in allogeneic transplant group(P0.01).Conclusion The expression of IL-12 is highly related with the development of acute cardiac allograft rejection in rats and may be used as monitoring index in acute rejection because of its important clinical values in early diagnostic of acute rejection and predicting the prognosis of allograft.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot