Title: Association of the allograft cytokine expression with acute allograft rejection in small bowel transplantation
Abstract: Objective To investigate the association of the allograft cytokine expression with acute allograft rejection in clinical and experimental small bowel transplantation, and search for sensitive cytokine expression in allograft for early diagnosis of acute rejection. Me- thods ①Two cases of short bowel syndrome patients were underwent living related small bowel transplantation. The histological changes as well as the sIL-2R, IL-4, IL-6, and IFN-γ expressions of the allograft in patients and rats were observed by using endoscopic surveillance. ②BN-LEW rats were underwent small bowel transplantation and divided to two groups: SBT group (group A, n = 20) and SBT+FK506 (2.5 mg/kg) group (group B, n = 20). The histopathologic examination was performed and the expressions of sIL-2R, IL-4, IL-6, and IFN-γ were detected at 1, 4, 7, 14, and 30 d postoperation. Results Severe acute rejection was happened in case one at 67 d posttransplant, and in case two at 20 and 80 d posttransplant. Expressions of sIL-2R and IFN-γ increased significantly when acute rejection happened but recovered quickly when rejection episode was controlled. In group A, graft expressions of IL-2Rα, IFN-γ, and IL-6 increased significantly at 1 d posttransplant and lasted for 14 days. In group B, graft expression of IL-2Rα, IFN-γ, and IL-6 increased significantly at 1 d posttransplant but recovered at 4 d posttransplant. Conclusion Up-regulated graft expressions of IL-2Rα and IFN-γ is associated with acute rejection, which could be a sensitive mark for diagnosis of acute rejection in small transplantation.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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