Title: Correlation of degree of coronary artery pathologic change with fibrinogen in CHD patients
Abstract: Objective To investigate the correlation of degree of coronary artery pathologic change with fibrinogen in CHD patients. Methods 96 coronary heart disease patients and 28 normal control patients were recruited for this study. Plasma fibrinogen was examined in all subjects. Cases with ≥50% stenosis in at least one of the three coronary vessels were angiographically defined as having coronary heart disease (CHD). CHD group was divided into two groups by the Gensini scoring: 28 cases of gentle coronary artery lesions (Gensini score20),68 cases of severe coronary artery lesions (Gensini score≥20). Results The plasma FIB levels of control group,gentle coronary artery lesions group,severe coronary artery lesions group were 2.75±0.57,2.82±0.85 and 3.75±1.00 respectively. The deference among the three groups was significant on the plasma FIB levels. Plasma FIB levels was positively correlated with coronary artery gensini scores,the correlation index was 0.471,P0.05,in CHD patients. There was no correlation between plasm FIB levels and the number of stenosised coronary vessels in CHD patients. Conclusions There was higher plasma FIB level in CHD patients. Plasma FIB levels was positively correlated with coronary artery gensini scores in CHD patients. Plasma FIB levels maybe reflect the degree of coronary artery pathologic change in CHD patients. There may have important role for intensive treatment of decreasing plasma FIB on retarding the development of coronary artery pathologic change in CHD patients.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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