Title: Effect of quercetin on the expressions of Bcl-2 and Bax in rats with brain glioma
Abstract: Objective To study the effect of quercetin on the expressions of Bcl-2 and Bax in rats with brain glioma.Methods A total of 30 female rats were randomly divided into 3 group(n =10 for each):sham group,model group and quercetin treatment group.The rat model of C6 glioma was established,and animals were killed 17 days after tumor graft.The expressions of Bcl-2 and Bax were observed by immunohistochemistry and Western blot.Results Compared with the sham group,the mean optic density(MOD) value of Bcl-2 positive expressions in brain tissues of the rats in model group was higher,but lower for Bax(P<0.01);and compared with the model group,the MOD value of Bcl-2 positive expressions in brain tissues of the rats in quercetin treatment group was lower,but higher for Bax(P<0.01).Conclusion Quercetin could down-regulate the expression of Bcl-2 and up-regulate the expression of Bax in rats with brain glioma.
Publication Year: 2016
Publication Date: 2016-01-01
Language: en
Type: article
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