Title: Expression and Significance of c-erbB-2、nm23 and PCNA protein in Breast Neoplasm
Abstract: s Objective: To study the expression and clinical significance of c erbB 2,nm23 and PCNA protein in breast neoplasm.Methods: 131 cases of benign and malignant breast neoplasm were examined by immunohistochemical S P method for c erbB 2 nm23 and PCNA protein.Among them,102 cases of breast carcinomas were examined for estrogen and progesterone receptor status.Results: There was a high expression of c erbB 2 in intraductal carcinoma,Paget's disease and infiltrating duct carcinoma,There was a high nm23 expression in infiltrating lobular carcinoma.There was a high expression of PCNA in intraductal carcinoma,medullary carcinoma and mucinous adenocarcinoma.There was a positive correlation between c erbB 2 and lymph node metastasis and PR.The expression of the nm23 protein was closely linked to age,histologic grade,lymph node metastasis,ER and PR in the breast carcinoma patients.There was a obvious correlation between PCNA and necrosis of the tumor.Conclusion: While the expression of c erbB 2 were negative and nm23 expression were pasivtive,there was a better prognosis.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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