Title: Preliminary studies on the mechanism of liver mitochondrial function injry following biliary obstruction
Abstract:Preliminary studies on the mechanisnl of liver mitochondrial function injury following biliary obstruction.METHODS: The changes of hepatic mitochondrial respiratory respiratory function,calcium conten...Preliminary studies on the mechanisnl of liver mitochondrial function injury following biliary obstruction.METHODS: The changes of hepatic mitochondrial respiratory respiratory function,calcium content,calcium uptake,malondialdehye(MDA) content and superoxide dismuthe(SOD) content following biliap obstruction in dogs were observed RESULTS: Each grouop of 2, 3, 4, 5 weeks following biliary obstnJction were compatal with sham groupl the results showed:hepatic mitochondrial respiratory control rate (RCR), Ca2+ - uptake and SOD content were reduced significantly (2weeks group P 0. 05, other groups P 0. 01 ); hepatic mitochondrial Ca2+ content was incnd significantly (2 weeksgrouP P 0. 05, other groups P 0. 01 ); hepatic mitochondrial MDA content were increased significantly (P 0. 01 ).Mithehondrial calcium conent and MDA content were highly negahve correlated with mitochondnal RCR(P 0. 01 ). CON'CLUSION:The hepatic mitochondrial respiratory function is obviously damaged after biliary obstiuchoin. Mitochondrial cal-cium overload and lipid peroaldation may be the mechanisms of mitochondroal dysfunctionRead More
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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