Title: The experimental study on six traditional chinese famous complex prescription on chronic viral hepatitis fibrosis in bandicot
Abstract: Objective:To analyze the chronic viral hepatitis fibrosis treated with traditional chinese medicine by Meta,and then rat experimental study of intersection herbs from Meta-analysis was performed to observe the preventive effect on liver fibrosis.Methods:Intersected herbs were acquired from six traditional chinese famous complex prescription based on Meta-analysis.Rats were divided into several groups by randomization which included model group,normal control group and the intersection of traditional Chinese medicine(single and compound) group.Liver fibrosis in rats were induced by carbon tetrachloride(CCL4) injections for 6 weeks,at the same time,treated with intersected herbs.Liver hematoxylin-eosinstaining(HE) staining and masson staining were performed.The fibrosis extent of liver masson′s stain was assessed by IPP software with area and integral optical density(IOD).Results:Intersection of herbs were salvia and astragalus.Compared to Salvia group and Astragalus group,the rats liver tissue of model group were obviously damaged,and their collagen fibers were increased.The Salvia+ Astragalus group was not damaged seriously,and their staging of liver fibrosis was obviously improved,the Area and IOD of collagen fibers were obviously decreased(P0.01).Collagen area and IOD in salvia group or astragalus group was lower than that in model group(P0.01),while the stage of liver fibrosis,collagen area and integral optical density IOD in Salvia+Astragalus group was significantly lower than that in salvia group or Astragalus group(P0.01).Conclusion:Salvia and astragalus could prevent the expression of liver fibrosis in rat.Salvia combined with astragalus is better than single drug.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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