Title: Blocking effect of Chinese herbs Yiganxian and PHGF on immuno-damaged hepatic fibrosis in rats
Abstract: IM To study the blocking effects of traditional Chinese herbs Yiganxian and promoting hepatocyte growth factor (PHGF) on immunodamaged liver fibrosis in rats.METHODS Abstract:Treatment groups with various doses (including dried medicinal herbs (12kg/L or 24kg/L) traditional Chinese herbs Yiganxian and PHGF were compared with model group and control group. Serum PCⅢ, HA and LN, pathological changes of hepatic tissues, and results of collagenous fibers and reticular fibers pathological picture of the liver were analyzed.RESULTS Serum PCⅢ (μg/L; in the 12kg/L group 924±252 vs 1596±370,P001) HA (μg/L; 2437±1068 vs 4812±1211,P001) LN (μg/L; 889±264 vs 1423±544,P001) in the treatment group were obviously lower than model group,and close to control group (μg/L; 916±326, μg/L 2366±1212, μg/L; 925±235). Pathological results under microscope and results of collagenous and reticular fibers pathological picture in the liver were better than model group especially in the group of lowdose traditional Chinese herbs (P001/P005).CONCLUSION Early administration of traditional Chinese herbs Yiganxian and PHGF can effectively prevent liver fibrosis in rats.
Publication Year: 1998
Publication Date: 1998-01-01
Language: en
Type: article
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Cited By Count: 6
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