Title: Study on the activities of pipercillin/sulbactam in vitro and in vivo
Abstract: OBJECTIVE The in vitro and in vivo activities of pipercillin/sulbactam (PIPC/SBT) were compared with those of pipercillin against some clinical isolates.METHODS The minimal inhibitory concentrations(MIC) and minimal bactericidal concentrations(MBC) of the isolates were detected by agar dilution and broth dilution.The mean effective dose(ED 50 ) were detected by the mice with systemic infection.RESULTS Against most of gram negative bacteria and anaerobe, pipercillin/sulbactam showed stronger activity than that of ampicillin/sulbactam(AMP/SBT) and pipercillin.Sulbactam, a β lactamases inhibitor, when combined with pipercillin showed a synergistic antibacterial activity with a more potent therapeutic effect than PIPC alone in mice with systemic infection caused by β lactamases producing strains. The relative hydrolysis rate of pipercillin/sulbactam was lower than that of pipercillin alone.CONCLUSION Combined pipercillin with sulbactam was more stable to β lactamases producing bacteria than pipercillin alone.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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