Title: Study on in vitro Antibacterial Activity of Piperacillin/Sulbactam
Abstract: OBJECTIVE: The antibacterial activity in vitro of pipercillin/sulbactam were evaluated.METHODS: Piperacillin/sulbactam (l:1,2:1,4:1)against 265 clinical isolated strains was compared with ampicillin/sulbactam, ticarcillin/clavulanic acid and piperacillin. Minimal was determined by use of agar dilution method, Inhibitory bactericidal concentrations (MBC) were measured by tube dilution method. RESULTS: The antibacterial activity of piperacillin/sulbactam(1:1,2:1,4:1) against common clinical isolates was of no difference and better than piperacillin. The antimicrobial activity of piperacillin/sulbactam(1:1,2:1,4:1) against G-bacilli was significantly better than other control antimicrobial agents .The inoculum size,pH and concentration of serum protein did not infuence the in vino activity of piperacillin/sulbactam (1:1,2:1,4:1).CONCLUSION: Piperacillin/sulbactam (1:1,2:1, 4:1) is a effective antibiotic containing β-lactamases inhibitor and valuable to be investigated.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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