Title: Correlation of CXCR4 and VEGF-C expressions with lymph node metastasis in human colon cancer
Abstract: Objective To investigate the relationship of the expressions of chemokine receptor CXCR4 and vascular endothelial growth factor C (VEGF-C) with lymph node metastasis in human colon cancer. Methods Immuohistochemistry was used to detect the expressions of CXCR4 and VEGF-C in 65 samples of human colon cancer. The relationship between CXCR4 and VEGF-C expressions and the clinicpathological diameters was statistically analyzed. Results The positive rate of CXCR4 expression with lymph node metastasis was higher than that without lymph node metastasis (57.9% vs 22.2%, P0.01). The positive rate of VEGF-C expression with lymph node metastasis was higher than that without lymph node metastasis (68.4% vs 25.9%, P0.01). The positive expression of CXCR4 was consistent with the positive expression of VEGF-C, and the expression levels of CXCR4 and VEGF-C were closely correlated with lymph node metastasis, but not with age, sex, tumor size, histological type, cellular differentiation and invasion depth. Conclusion CXCR4 and VEGF-C expressions may become predictors for the lymphatic metastasis of colon cancer.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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