Title: Expression of CD44v6 and E-cadherin in Human Renal Cell Carcinoma and Their Significance
Abstract: Objective To study the expression and significance of CD44v6 and E-Cadherin( E-cd) in human renal cell carcinoma. Methods Immunohistochemical method was used to detect CD44v6 and E-cd expression in 20 normal renal tissues and 72 primary renal cell carcinoma tissues. Results The postive expression rate of CD44v6 in normal renal tissues and primary renal cell carcinoma tissues was 15 00% and 66 67% respectively with significant difference (P0 01). Abnormal expression rate of E-cd in normal renal tissues and primary renal cell carcinoma tissues was 0 and 51 39% respectively with significant difference (P0 01). Both the postive expression rate of CD-44v6 and abnormal expression rate of E-cd were significantly associated with the histological grades and clincopathological stages of the primary renal cell carcinoma. Conclusion CD44v6 and E-cd might be valuable markers in assessing biological behavior, invasion and metastatic potential of human renal cell carainoma.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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