Title: Changes and significance of lung cell apoptosis in rat after chest impact
Abstract: Objective To explore the characteristics of lung injury, lung cell apoptosis and its significance in the injury. Methods An animal model of severe lung impact injury was established in Wistar rat by impacting the right chest. The pathological changes and cell apoptosis were observed with flow cytometry, immunochemical and other morphological methods. Results The right lung showed obvious hyperaemia, congestion and edema and with extensive blood extravasation and destruction of tissues, but only edema was seen in the left lung. The apoptotic rate in bilateral lung was significantly higher at 24th h post injury than that in pre injury ( P 0.01). The apoptotic rate in right lung rose rapidly at hour 48, reached a peak at hour 72 after the injury and then declined. It came to the normal level 1 week after injury. The rate of apoptosis in left lung reached a peak 48 h after injury and recovered obviously at 72 h, which was closed to pre injury level. Significant difference was found in the apoptosis between right lung and left lung ( P 0.05). The apoptotic cells in right lung were mainly bronchial, vascular endothelial and alveolar epithelial cells 24 h after the injury, and were inflammatory cells at the 72 nd h. Conclusion The stress wave mainly affects bronchial, vascular endothelia and alveolar epithelia, so the apoptosis in these regions is one of major causes of lung edema and secondary injury after impact.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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Cited By Count: 1
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