Title: To explore the pathogenesis of lung injury during multiple system organ failure after traumatic shock
Abstract: Objecctive: To explore the pathogenesis of lung injury during multiple system organ failure (MSOF) after traumatic shock by using intestinal ischemia reperfusion model of the rat.Methods: We nipped the root part of the upper mesentery artery to cause intestinal ischemia of the rat,then took the sample after reperfusing.We detected the levels of NO secreted by the alveolar macrophage and NOS in lung tissue; and we also detected the pressure of O 2 and CO 2 in the anticoagulant blood taken from the left ventricle.Results:The level of NO secreted by the alveolar macrphage and NOS in lung tissue in model group were remarkably higher than those in control group(respectively P 0.001, P 0.05).The pressure of O 2 in artery blood in model group was obviously lower than that in control group,but the pressure of CO 2 was higher than that in control group.Conclusion:NO was over synthesized and secreted by the active alveolar macrophage during intestinal ischemia reperfusion of the rat,which may be an important factor of lung injury after traumatic shock.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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