Title: The application of dehydroepiandrosterone in infertile patients with diminished ovarian reserve
Abstract: Objective: To investigate the effects of dehydroepiandrosterone( DHEA) on patients with diminished ovarian reserve( DOR). Methods: Thirty patients with DOR were treated with DHEA for 3 months. The ovarian reserve indexes before and after DHEA treatment were compared,and the induced ovulation rate,clinical pregnancy rate and abortion rate after treatment were observed.Results: Compared with before treatment,the levels of follicle-stimulating hormone( FSH),FSH / lutenizing hormone and estradiol on the3 rd day of menstrual cycle obviously decreased( P 0. 01),and antral follicle count significantly increased after 3 months of treatment with DHEA( P 0. 01). The induced ovulation in 24 cases were successful,the ovulation rate was 80. 00%. The pregnancy in 11 cases were successful,the cumulative pregnancy rate was 45. 83%. Two pregnancy cases for 2 months aborted,the abortion rate was 18. 18%.Conclusions: DHEA can effectively improve the ovarian reserve function,sensitivity of fertility drugs,success rate of induced ovulation and egg quality,obtain the good clinical pregnancy rate,and decrease the adverse reaction.
Publication Year: 2016
Publication Date: 2016-01-01
Language: en
Type: article
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