Title: Expression and clinical significance of LRP,GST-π and TOPOII in breast cancer
Abstract: Objective To investigate the cxpressinon of LRP,GST-π and TOPOⅡ in breast cancer and evaluate its clinical significance Methods 80 cases of breast cancer were stained immunohistochemically for LRP, GST-π and TOPOⅡ using respective antibody and researching correlated results with tumor clinic stages. Results The expression of LRP, GST-π and TOPOⅡ in breast cancer were 80.00%(64/80),65.00%(52/80),55.00%(44/80) respectively.The expression of LRP in clinic stageⅡ,Ⅲ were higher than stage Ⅰ, the expression of GST-π in clinic stage Ⅲ were higher than stageⅠ,Ⅱ and the expression of TOPOⅡ in clinic staegⅠ, Ⅱ were higher than staeg Ⅲ. There was relation between LRP and GST-π. There were no relations between lRP, GST-π and TOPOⅡ. Conclusion A combined analysis of the expression of LRP, GST-π and TOPOⅡ in breast cancer may contribute to the selection of drug in chemotherapy and prognosis evaluation of breast caner.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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