Title: Amifostine Pretreatment for Protection Angainst Cisplatin-induced Nephrotoxicity
Abstract:OBJECTIVE Amifostine,a cytoprotector of broad-spectrum,protects normal tissues from the toxic effects of certain anticancer drugs.This study aims to observe the protective effect of amifostine angains...OBJECTIVE Amifostine,a cytoprotector of broad-spectrum,protects normal tissues from the toxic effects of certain anticancer drugs.This study aims to observe the protective effect of amifostine angainst cisplatin-induced nephrotoxicity.METHODS Thirty-five Sprague-Dawley rats were randomly divided into 5 groups:control group(0.9% saline solution),cisplatin 5 mg·kg-1 group,cisplatin 7.5 mg·kg-1 group,cisplatin 5 mg·kg-1+amifostine 200 mg·kg-1 group and cisplatin 7.5 mg·kg-1+amifostine 200 mg·kg-1 group.Organ coefficient of kidneies,serum BUN,creatinine were measured.Renal histopathological lesions were examined by light microscopy.RESULTS Compared with control group and cisplatin 5 mg·kg-1+amifostine 200 mg·kg-1 or cisplatin 7.5 mg·kg-1+amifostine 200 mg·kg-1 group,serum BUN and creatinine were significantly elevated in cisplatin 5 mg·kg-1 and cisplatin 7.5 mg·kg-1 groups(P0.05 or P0.01).The organ coefficients of kidneies with amifostine were decreased obviously.The rate of nephroprotection in pathological grade was 61.5% and 56.8%,respectively.CONCLUSION Amifostine is able to protect the nephrotoxicity induced by cisplatin.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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