Title: Does selection of combination treatment of cisplatin and cyclophosphamide
Abstract:AIM: To investigate the anticancer effects and toxicity of cisplatin and cyclophosphamide used alone and in combination in treatment of the mice models with sarcoma 180 (S 180). METHODS: The anticance...AIM: To investigate the anticancer effects and toxicity of cisplatin and cyclophosphamide used alone and in combination in treatment of the mice models with sarcoma 180 (S 180). METHODS: The anticancer effects and toxicity were evaluated by the inhibition rate, the indexes of thymus and spleen. The growth of tumor was observed by mice models of transplant tumor. RESULTS: The inhibition rate of co-treatment of cisplatin ( 5.0 mg·kg -1) and cyclophosphamide ( 7.5 mg·kg -1) increased 13.6%- 29.6%, and 33.5%- 34.3% in comparison with cisplatin and cyclophosphamide, respectively. The inhibition rate in the groups of co-treated was higher than that of in the group of cisplatin and cyclophosphoamide ( 7.5 mg·kg -1)(P 0.01- 0.001). CONCLUSION: Co-treatment of cisplatin in lower dose with cyclophosphamide shows a synergetic anticancer effect in mice models.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot