Title: Significance of apoptosis and expression of the genes related to apoptosis in esophageal squamous cell carcinogenesis
Abstract: Objective To investigate the regulation of changes and significance of apoptosis and expression of the genes related to apoptosis in esophageal squamous cell carcinogenesis.Methods Immunohistochemical staining and TUNEL staining were used to detect the expression of bcl-2,p53 and the changes of apoptosis for 72 patients with esophageal squamous cell carcinoma (including normal mucosal epithelium, dysplasia and invasive carcinoma), respectively.Results The expression of bcl-2 and p53 in dysplasia and invasive carcinoma was significantly higher than normal mucosal epithelium(P0.01),and it was correlated closely with the metastasis of lymph node(P0.05).The expression of p53 correlated with the depth of invasion and the age of patients. TUNEL staining results showed apoptotic index in dysplasia and invasive carcinoma increased markedly(P0.05 or P0.01).Bcl-2 and p53 positive lesions had lower apoptotic index than its negative lesions in the same stage, respectively(P0.05).Conclusions There is close relation between apoptosis and expression of the genes related to apoptosis and esophageal squamous cell carcinogenesis. Immunohistochemical method in situ detection technique may be used as important molecular markers in early diagnosis and prognosis of esophageal squamous cell carcinoma.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot