Title: Expression of Bcl-2 and Its Correlation With Vascular Endothelial Growth Factor in Squamous Cell Carcinoma of the Cervical
Abstract: Objective To investigate the expression of significance of bcl-2 as a member of inhibitor apoptosis gene family and its correlation with vascular endothelial growth factor (VEGF) protein in the tissues of squamous cell carcinoma of the cervical. Methods Immunohistochemical techniques were used to detect the expression of bcl-2 and Western Blotting technique was used to detect the expression of VEGF protein in 45 cases of squamous cell carcinoma of the cervical tissues, 34 cases of CIN tissues and 10 cases of normal cervical tissues, respectively. The apoptosis index (AI) was detected by TUNEL method. Results The positive expressions of bcl-2 and VEGF protein in squamous cell carcinoma of the cervical tissues were respectively 51.11% and 62.22% which were significantly higher than CIN tissues(P0.05). There was no experession in normal cervical tissues. The expression of bcl-2 had no significant correlation with metastasis of squamous cell carcinoma of the cervica and the degree of differentiation. There was a significant correlation between the high expression of bcl-2 and VEGF (χ2=5.148, P0.05). Conclusion The high expression of bcl-2 in squamous cell carcinoma of the cervica suggests that it may play an important role in the mechanism of genesis and development of squamous cell carcinoma of the cervica. The correlation between the expression of bcl-2 and VEGF indicate that bcl-2 may promote the metastasis of squamous cell carcinoma of the cervica through up-regulating the expression of VEGF, meanwhile, VEGF might inhibit the apoptosis of neoplastic cell by inducing the expression of bcl-2.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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