Title: Clinical significance and assay of peripheral blood somatostatin,TNF-α,IL-6,sIL-2R in patients with gastrointestinal cancer
Abstract: AIM: To observe the changes of peripheral blood somatostatin(SS),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and soluble interleukin-2 receptor(sIL-2R) levels in patients with gastrointestinal cancer.METHODS: The subjects were divided into 4 groups: 23 cases in normal control group,37 patients in gastric cancer group,23 patients in colon carcinoma group and 29 patients in rectal cancer group.The levels of TNF-α,IL-6 and sIL-2R were assayed with ELISA and SS was assayed with RIA.RESULTS: Compared with that in control group,the level of SS decreased significantly in gastric cancer group,colon cancer group and rectal cancer group,but the serum levels of IL-6 and sIL-2R increased remarkably.The levels of IL-6 and sIL-2R were significantly different in the 3 types of gastrointestinal cancer(P0.05).Significant difference was found in the level of TNF-α when control group and gastric cancer group were compared with colon and rectal cancer groups(P0.05).CONCLUSION: The detection of the changes of peripheral blood SS,TNF-α,IL-6 and sIL-2R is of some clinical significance in the diagnosis and differentiation of patients with gastrointestinal cancer.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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