Title: Clinical observation on the clinical efficacy and safety of the regimen of pasiniazid levofloxcin ethambutol streptomycin' for lesions of the new pulmonary tuberculosis complicated with chronic hepatitis B
Abstract: Objective To observe the clinical efficacy and safety of the treatment regimen of Pasiniazid Levofloxcin Ethambutol Streptomycinfor lesions of the new pulmonary tuberculosis complicated with chronic hepatitis B.Methods By random group-matching,60 cases with lesions of the new pulmonary tuberculosis complicated with chronic hepatitis B were divided into the treatment group(30 cases) and control group(30 cases) .The chemotherapy regimen adopted:the treatment group used Pasiniazid(D),Levofloxcin(V),Ethambutol(E),Streptomycin(S),while the control group used Isoniazid(H),Rifampicin(R),Pyrazinamide(Z) and Ethambutol(E) .The course of treatment was 9 months for both groups.Results Fifty-five cases completed the treatment with 28 cases in the treatment group and 27 cases in the control group.In the treatment group,the sputum negative conversion rate by the end of the 9th month was 96.4% in smear;while in the control group,the rates were 92.6% respectively.At the end of the treatment,X-rays evidently improved the assimilation of focuses up to 96.4% in the treatment group and 96.3% in the control group;there was no significant difference in the treatment outcome in the two groups(P 0.05) .The re-checking in 2 years showed that the positive conversion rate was 3.5% in treatment group and 3.7% in control group with no significant difference between the two groups.The lesions of the liver was 14.3% in the treatment group and 66.7% in the control group with significant difference in the two groups(P 0.01) .Conclusions The regimen ofPasiniazid Levofloxcin Ethambutol Streptomycinschemeis effective and reliable to cure lesions of the new pulmonary tuberculosis complicated with chronic hepatitis B and it is easy to expand the application of this regimen in the clinical practice.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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