Title: Analgesic Effect of Buccal Acupuncture and Changes of β-EP and CCK-8 in Cerebrospinal Fluid of Experimental Rheumatoid Arthritis Rabbits
Abstract: Objective To observe the analgesic effect of buccal acupuncture and explore its central analgesic mechanism in experimental rheumatoid arthritis rabbits.Methods A total of 48 rabbits were randomly divided into normal control group,model group,body-acupuncture group,buccal acupuncture group,and the later 2 groups were further randomized into 0 h and 1 h subgroups,with 8 cases in each group.The rheumatoid arthritis model was established by egg-albumin.For rabbits of body-acupuncture group,bilateral Xiyan(EX-LE5) and Zusanli(ST 36) were punctured for 1 min,with the needle retained for 30 min.For rabbits of buccal acupuncture group,acupuncture was applied to xi for 1 min,with the needle retained for 30 min.The pain threshold was detected with K+ import stimulation method,and β-EP and CCK-8 contents in cerebrospinal fluid were assayed with radioimmunoassay.Results Compared with the control group,the pain threshold of model group lowered significantly(P0.01).Compared with model group,the pain threshold of body-acupuncture group and buccal acupuncture group increased significantly(P0.01).Compared with body-acupuncture group,the pain threshold of buccal acupuncture group at 0 h increased significantly(P0.01).Both β-EP and CCK-8 contents of buccal acupuncture group at 0 h were significantly higher than those of body-acupuncture group(P0.01,P0.05).There were no significant differences in contents of β-EP and CCK-8 between buccal acupuncture group and body-acupuncture group.Conclusion The instant analgesic effect of buccal acupuncture is superior to body-acupuncture.Buccal acupuncture can effectively raise cerebral β-EP and CCK-8 contents,which may contribute to its central effect.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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