Title: Effects of Selenium on the Proliferation and Differentiation of Embryo Spinal Cord Neurons of Rat in Vitro
Abstract: Objective: To explore the effects of selenium on the proliferation and differentiation of spinal cord neurons of fetal rats in vitro. Methods: Dissociated spinal cord neurons of fetal rat was cultured in the medium contained or no contained selenium. The effects of seleniumon on the neurons were studied by Lowry's methods and by the cellular morphology.Results: The spinal cord neurons of embryo rats could grow and develop in vitro. The selenium of low dose (1.0μmol/L)can promote the proliferation and differentiation of embryo spinal cord neusons; The selenium of high does (≥50.0μmol/L)may inhibit the proliferation and differentiation of the neurons. Conclusion: There were positive and negative effects of selenium on embryo spinal cord neurons.The character of effect dependented upon the dose of selenium.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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