Title: The Clinical Value of HE4 and CA125 Combined with sB7-H4 in Early Diagnosis of Ovarian Cancer
Abstract: Objective: To explore the clinical value of three markers in early diagnosis and prognosis of ovarian cancer by detecting the serum level of HE4,CA125 combined with sB7-H4 in ovarian cancer patients.Method:HE4,CA125 and sB7-H4 serum levels were detected in 58 cases of different stage ovarian cancer patients and 35 healthy women as controls by ELISA.And observed three indexes level changes before and after operation.Result:The serum HE4,CA125 and sB7-H4 levels before operation of patients with ovarian cancer were significantly higher than the control group(P0.01).The serum level of three indexes were increased with cancer staging(P0.01).The serum level of three indexes in ovarian cancer patients after operation significantly below before operation level(P0.001).The detection sensitivity of HE4,CA125 and sB7-H4 was respectively 89.66%,77.59% and 82.79%.The specificity was respectively 97.37%,84.21% and 81.59%.The sensitivity and specificity of three indexes joint test were 94.83% and 94.74%.The sensitivity of three indexes joint test was higher than single detection(P0.05),and the specificity was higher than those of CA125 and sB7-H4,but belower than that HE4 detection.Conclusion:The HE4 has important significance in the diagnosis of ovarian cancer,especially,its sensitivity and specificity are all better than CA125 and sB7-H4 in the diagnosis of early ovarian cancer,the detection of HE4,CA125 combined with sB7-H4 can elevate the early diagnosis rate of ovarian cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 3
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