Title: Elevated plasma homocysteine levels of "H" hypertension contribute to the risk of secondary cerebrovascular disease in a large prospective stroke population
Abstract: Objective To assess whether elevated plasma homocysteine levels of H hypertension contribute to the risk of secondary cerebrovascular disease in a prospective cohort of patients with first onset stroke.Methods A total of 100 stroke patients(35~74 years)were followed-up during 3 years.Cox proportional-hazards models were used to examine the association between homocysteine and secondary cerebrovascular disease.Results During a median of 3 year follow-up,100 secondary cerebrovascular diseases were documented,including 25 recurrent strokes.After adjustment for age,sex,and conventional vascular risk factors,high homocysteine concentration was associated with increased risk of 1.54 fold for secondary cerebrovascular disease[relative risk(RR)1.54,95% CI 1.18~2.21;P0.01]and 1.74 fold for stroke recurrence(RR 1.74,95% CI 1.3~2.3;P0.001)in comparison of the highest to lowest category.Conclusions Our findings suggest that elevated plasma homocysteine levels of H hypertension are associated with increased risk of secondary cerebrovascular disease and stroke recurrence in the patients with first onset stroke.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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