Title: Effect of estradiol on the SOD activity and the MDA content of cerebral tissue after ischemia reperfusion in gerbils undergone ovariectomy
Abstract: Objective: To observe the protective effect of estradiol on nerve cell injury caused by free radicals after cerebral ischemia reperfusion in gerbils undergone ovariectomy Methods: Forty female gerbils were randomly divided into false operation group,cerebral ischemia reperfusion group,ovariectomy control group and estradiol group.The common carotid arteries of both sides were kept closed by clips to replicate cerebral ischemia reperfusion model for 7min and then reperfused for 12 hours.The SOD activity and the changes of MDA content in cerebral tissue were examined,and pathologic changes were observed in the nerve cells in hippocampal CA1.Results: In the cerebral ischemia reperfusion group and ovariectomy control group,the SOD activity was obviously reduced and the MDA content was clearly increased,which showed significant difference compared with those in the false operation group(P 0.01).In estradiol group,the SOD activity was obviously increased and the MDA content was clearly reduced,which showed significant difference compared with those in cerebral ischemia reperfusion group and ovariectomy control group(P 0.01).The injury of nerve cells in hippocampal CA1 and the brain cell edema were obvious while in estradiol group,the injury of nerve cells was clearly reduced.Conclusion: Preventive administering of estradiol can obviously reduce the injury caused by cerebral ischemia reperfusion,and thus has a protective effect on free radical injury of cerebral ischemia reperfusion.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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