Title: Effects of conventional and intensive exercise training on the expression of nestin in the hippocampus dentate gyrus after cerebral ischemia-reperfusion
Abstract: Objective:To explore the effect of conventional and intensive exercise training on the expression of nestin in the hippocampus dentate gyrus (DG) after cerebral ischemia-reperfusion. Method:Fifty-four Wistar rats were randomized into a control group (Group A), a conventional exercise training group (Group B), and an intensive exercise training group (Group C). The middle cerebral arteries (MCA) of rats were occluded for 1 hour, then reperfused for 7th, 14th and 21st days. Immunohistochemistry was used to detect the expression of nestin in the hippocampus dentate gyrus of rats. Result:There was the largest number of Nestin-positive cells in the DG in all groups on the 7th day after cerebral ischemia-reperfusion. Nestin-positive cells in ipsilateral DG were significantly more than those in the counter part at different time points. Significant increase of Nestin expression were detected in rats of Group B and C at different time points after cerebral ischemia-reperfusion, compared with Group A. We also found that there were no significant difference of Nestin-positive cells between Group B and Group C. Conclusion:The increase of Nestin-positive cells in the DG existed time-regularity and in situ proliferation characteristic after cerebral ischemia-reperfusion. Exercise training can significantly promote the expression of Nestin. But intensive exercise training can not enhance this function.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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