Title: Jiannao Recipe promotes neurogenesis of hippocampus in rats with cerebral ischemia
Abstract: Objective To explore the effect of Jiannao Recipe on neurogenesis in the dentate gyrus and spatial learning and memory of rats with cerebral ischemia.Methods SD rats were randomly divided into sham group,model group and treatment group.The cerebral ischemia model was established by clamping the bilateral common carotid arteries permanently.Rats in the treatment group were orally administrated with Jiannao Recipe after operation,the model group with NS.Bromodeoxyuridine(BrdU) was used to label proliferating cells in the dentate gyrus.Spatial learning ability was tested by using Morris water maze test.Results BrdU positive cells in the dentate gyrus of the model group and the treatment group all reached the peak at day 7 after ischemia.BrdU Positive cells of the treatment group were obviously more than those in the model group at day 7,14,20 and 28 after ischemia(P0.05orP0.01).Morris water maze test displayed the average escape latency of the treatment group was obviously shorter than that of model group at day 14 after ischemia(P0.05).Conclusions Jiannao Recipe can promote neurogenesis in the dentate gyrus of rats with cerebral ischemia continually,and improve spatial learning ability.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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