Title: The antioxdative effects of Shen Mai injection on myocardial ischemia/reperfusion injury in rabbits
Abstract: Objective To investigate the protective effects of Shen Mai injection on myocardial ischemia/reperfusion injury in rabbits. Methods The model was made by the ligating and reperfusing the left descending coronary artery in rabbits. Serum level of malondialdehyde(MDA) and the activity of Superoxide Dismutase(SOD) in different time points was observed. Results In myocardium ischemia reperfusion group(MIR) Ischemia 40 minutes later the activity of SOD in serum was decreased (P0.05) the level of MDA in serum was increased (P0.05). After reperfusion the activity of SOD in serum continue decreased the level of MDA in serum continue increased (P0.05). The abnormal changes of myocardium morphology were obvions during MIR After Shen Mai injection administration above mentioned abnormal changes of all the parameters and hepatocytes morphology were all alleviated remarkably (P0.05). Conclusion Shen Mai injection may protect myocardium ischemia/reperfusion injury.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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