Title: Expressions and correlation of survivin and cyclooxygenase-2 in pancreatic andenocarcinoma tissues
Abstract: AIM: To investigate correlation of the expression of survivin and cyclooxygenase 2 (COX 2) and the clinicobiological behavior in human pancreatic adenocarcinoma tissues. METHODS: The expressions of survivin and COX 2 in 51 cases of human pancreatic ductal adenocarcinoma were detected with immunohistochemistry of Envision. RESULTS: The expression rates of survivin and COX 2 in pancreatic ductal adenocarcinoma were 80.4% and 74.5%, respectively, and no expression of survivin and COX 2 in the 11 cases of adjacent normal tissues was found. The survivin expression was significantly correlated with the histological grade ( P 0.01), but not with the clinical stages and lymph node metastasis status ( P 0.05). The COX 2 expression was significantly correlated with the clinical stages and lymph node metastasis status ( P ≤ 0.05) but not with the histological grades ( P 0.05). The expression of surviving and COX 2 had no correlation with age, sex, tumor size and location but the expression of survivin was closely correlated with that of COX 2 ( P 0.05). CONCLUSION: The intimate relation of survivin and COX 2 may play an important role in the tumorigenesis and tumor progression in pancreatic cancer, and they may provide some new targets for the therapy of pancreatic cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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