Title: Effects of rosiglitazone on the expression of adiponectin in early diabetic nephropathy
Abstract: Objective To investigate the effects of rosiglitazone on the expression of adiponectin in early diabetic nephropathy.Methods Eighty patients with type 2 diabetes and early diabetic nephropathy were randomly divided into two groups:rosiglitazone group(n = 40) and control group(n = 40).Patients in rosiglitazone group received rosiglitazone 4 mg/d and other treatment of lowering blood glucose while those in control group were treated without rosiglitazone.The fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG),HbA1c,fasting insulin(Fins),high sensitive C-reactive protein(hsCRP),adiponectin(APN),urine microalbumin(MA),and urine creatinine(UCr) were measured before and 12 weeks after treatment.Results The FBG,2hPG,HbA1c,Fins,HOMA-IR,and urine albumin excretion ratio(UAER) were significantly decreased in the two groups after treatment(P 0.05).HOMA-IR and UAER were decreased significantly in rosiglitazone group than those in control group(P 0.05).The level of hsCRP was decreased significantly(P 0.05),while the concentration of APN was increased significantly(P 0.05) in rosiglitazone group after treatment,but were not changed in control group.Conclusion Rosiglitazone may play a protective role in diabetic nephropathy by inhibiting inflammatory response.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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