Title: Evaluation of bioequivalence of domestic glimepiride tablet in Chinese healthy male volunteers
Abstract: AIM: To compare the bioequivalence of glimepiride tables and capsules with a single dose. METHODS: Twenty Chinese healthy male volunteers were enrolled in a randomized crossover study with a single oral dose 3 mg of two formulations respectively. The blood drug concentration in serum was measured by HPLC, and the pharmacokinetic parameters were calculated by 3p97 software and compared by two one side t test. RESULTS: The parameters of the tables and the capsules were( 1.23 ± 0.19 ) and ( 1.31 ± 0.22 ) mg·h·L -1 at AUC (0-t) ,( 1.32 ± 0.20 ) and ( 1.45 ± 0.24 ) mg·h·L -1 at AUC (0-inf) ,( 0.30 ± 0.05 ) and ( 0.30 ± 0.06 ) mg·L -1 at C max ,( 6.6 ± 2.5 ) and ( 9.3 ± 7.9 ) h the peak time (T peak ), respectively. There were no significant differences between the two formulations. F was 96.4 ± 21.1 calculated by AUC (0-t) and 96.4 ± 21.1 by AUC (0-inf) . CONCLUSION: Glimepiride tables and capsules are of bioequivalence.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot