Title: Expressions of p16 and cyclin D1 in oral squamous cell carcinoma and their significance
Abstract: Objective To study the expressions of p16 and cyclin D1 proteins in oral squamous cell carcinomas (OSCCs) and their association with clinical features and cell proliferation. Methods Immunohistochemical method was applied to detect the expressions of cyclin D1 and p16 in 49 cases of oral squamous cell carcinoma and 20 pieces of normal oral mucous membrane. The expression of Ki-67 labeling index(LI)was also examined as an index of cell proliferative activity. Results p16 expression was significantly lower and the expressions of cyclin D1 proteins and Ki-67 were significantly higher in OSSCs than in the normal oral membrane(P 0.05 for both comparisons). The overexpression of cyclin D1 was correlated with clinical stage and lymph node metastases(P 0.05) and the loss of p16 expression was correlated with lymph node metastases(P 0.05). Overexpression of p16 was negatively associated with cyclin D1 and Ki-67 expression(r=-0.598, r=-0.658,P 0.05). Conclusion Either loss of p16 expression or overexpression of cyclin D1 or both may be involved in oncogenesis and development of OSCCs and loss of p16 expression may also be related to the differentiation, metastasis, and prognosis of the tumor.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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