Title: Effects of soybean isoflavone on the serum lipid metabolism and endothelial dilation function of artery in ovariectomized rats
Abstract: Objective:To investigate the effect of soybean isoflavone on the serum lipid metabolism and the endothelium-dependent dilation function of artery in ovariectomized female rats. Methods: Fifty SD female rats, two months old, were randomly assigned to five groups:A (sham operated); B (ovariectomized and hyperlipid food); C (OVX and hyperlipid food and 20 mg/(kgbw·d) soybean isoflavone); D (OVX and hyperlipid and 60 mg/ (kgbw·d) soybean isoflavone); E (OVX and hyperlipid and 180 mg/(kgbw·d) soybean isoflavone). Beginning from 7 days after surgery, the rats were treated intragastrically with soybean isoflavone or solvent once daily respectively for a period of 60 days. Serum TC, TG, HDL-cholesterol, LDL-cholesterol et al. were measured. At the end of the experiments, endothelium-mediated dilation function of artery was also evaluated.Results: Group B had a significant increase in serum TC,TG,LDL-C. HDL-C contents were significant increased in C,D and E groups than that in group B; Moreover, soybean is oflavone could improve the endothelium-mediated dilation in ovariectomized female rats. Conclusions: Soybean isoflavone can not only decrease TG,TC and LDL-C, but also increase HDL-C. Soybean isoflavone can improve the endothelium-mediated dilation function of artery.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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