Title: Application of Sufficient Doses of Nebulized Budesonide in the Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease with Severe Airflow Restriction
Abstract: Objective:To evaluate the clinical application value of nebulized budesonide (NB) on acute exacerbated chronic obstructive pulmonary disease (COPD) with evere airflow restriction. Methods:Ninty patients with acute exacerbations of COPD with severe airflow restriction (30%≤FEV150%) were divided into three groups randomly,inculuding 2 mg NB every 8h;24 mg oral methylprednisolone every day;and the control group didn't received any corticosteroid with duration treatment was 10 days, respectively. The lung function, arterial blood gas analysis, dyspnea score and adverse reaction were observed. Results: Compared to control group, there was a significantly greater change in postbronchodilator (支气管扩张剂 SB)FEV1, PaO2, PaCO2 and dyspnea score of two treatment groups (P0.05);the difference between NB and methylprednisolone group was no significant (P0.05);fewer side effects were recorded in NB and control group than in methylprednisolone group (P0.05). Conclusion: There was similiary effects between NB and methylprednisolone group. Therefore, sufficant doses of nebulized budesonide with mild generalized side effects and good safety profit maybe an alternative to oral corticosteroid in treating acute exacerbation of COPD.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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