Title: A study on apoptosis and proliferation in different colon mucosa
Abstract: ? Objective To study on the significance of apoptosis and proiferation in genesis and development of human colon carcinoma (HCC).Methods TUNEL and PCNA immunohistochemical staining was used to test apoptosis or proliferation of different mucosal cells in 30 cases of HCC,20 cases of colon adenoma and 10 cases of normal control.Results Positive staining of both kind was located in cell nuclear.Apoptosis rate was significantly higher in HCC than in colon adenoma (P0.01) and in nomal mucosa (P0.01).PCNA positive percentage was significantly different among each group (P0.01).Apoptosis and positive percentage of PCNA had significant correlation (P0.001).Conclusions Apoptosis rate and PCNA expression level in HCC are closely associated with the differentiation,clinical stage,metastasis and prognosis of the tumor,and thus probably become objective markers in predicting prognosis of HCC. 〔
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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