Title: Efficacy and Safety of Sufentanil in Patient-controlled Intravenous Analgesia Following Spinal Column Surgery:A Clinical Study
Abstract: OBJECTIVE:To evaluate the pain-relieving and sedative efficacy and safety of sufentanil in patient-controlled intravenous analgesia after spinal column surgery.METHODS:60 patients undergoing selective spinal column surgery were randomized to either fentanyl group or sufentanil group.General anesthesia was performed for all the 60 cases,with tracheal catheter withdrawn and patient-controlled intravenous analgesia(PCIA) performed after completion of surgery when patients had regained consciousness.The analgesic efficacy within 24 hours was evaluated using visual analogue score(VAS),VRS score,Ramsay score and the adverse effects were recorded.RESULTS:In sufentanil group,effective analgesic efficacy was obtained,and the VAS score was significantly lower but the VRS score was significantly higher than in fentanyl group(P 0.05).Analgesic failure was noted in 5 cases in fentanyl group,and in this group,Ramsay scores at different time points were significantly higher than in fentanyl group(P0.05).The differences in the incidence of adverse drug reactions between the two groups were not statistically significant(P0.05).CONCLUSION:Sufentanil is proved to be safe and effective with reliable analgesic and sedative efficacy but fewer side effects for PCIA patients.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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