Title: An immunohistochemical comparison of the relationship of p53 protein and PCNA expression to MVD in tumor tissues between osteosarcoma and giant cell tumor
Abstract: Objective: To compare expressions of p53 protein. PCNA and MVD between osteosarcoma and giant cell tumor as well as their pathological biological significance. Method: The expression of p53 protein, PCNA and MVD of 40 osteosarcoma and 40 differented-grade giant cell tumor were determined by immunohistochemistry and morphological measure. Result: The frequency of PCNA of grade Ⅱ~Ⅲ giant cell tumor was obviously higher than grade I; meanwhile, the expression of p53 protein, PCNA in MVD≥5 group significantly increased in comparison to MVD5 group. So did the expression of p53 protein of osteosarcoma. Conclusion: It may have a valuable index to evaluate the prognosis of osteosarcoma and giant cell tumor by detecting the expression of p53 protein, PCNA as well as the MVD in tumor tissues.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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