Title: Effects of myocardiac troponin I during isoflurane preconditioning against ischemia-reperfusion injury in patients undergoing cardiopulmonary by-pass operation
Abstract: Aim To evaluate the myocardial protection of isoflurane preconditioning against ischemia-reperfusion injury and investigate the probably mechanism of this effect.Methods Forty patients undergoing open heart surgery with cardiopulmonary by-pass(CPB)were divided randomly into two groups: isoflurane preconditioning group (group I) and control group (group C).The patients of both group D and group C were anesthetized with high dose fentanyl(30 μg·kg -1 ).The patients of group D underwent 10 min of 1 minimal alveolar concentration(MAC) of isoflurane followed by 5 min washout before aorta clamping,but the group C only underwent 15 min 100% O 2 before aorta clamping.The central venous blood samples were collected for the measurement of CK-MB and myocardiac troponin I(cTnI) level before anesthesia(T 0)and immediately(T 1),2 h(T 2),6 h (T 3),24 h(T 4),48 h(T 5) after aorta in opening.The rate of spontaneously rebeating of hearts were observed after aorta opening.Results After reperfusion,the concentration of CK-MB(T 2,T 3)and cTnI (T 1~T 5)n group I were significantly decreased than those in group C, meanwhile, the rate of spontaneously rebeating of hearts in group I was higher than that in group C. Conclusion These results indicate that pre-ischemic administration of isoflurane dose cause anaesthetic-induced preconditioning to protect myocardium against ischemia-reperfusion injury.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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